91196      Renin Activity
Specimen:
  Collect: One 4 mL Lavender (EDTA)  
  Submit: 2 mL (Min:1.5 mL) Plasma. Submit Frozen. Submit in a Standard Transport Tube.  
  Special Handling: Critical Frozen
Separate from cells ASAP
If upright specimen collected, patient should be upright (seated or standing) for at least 2 hours. 
  Rejection Criteria: Hemolyzed specimens 
  Stability: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 Month(s); Incubated: Unacceptable 
Methodology: Radioimmunoassay (RIA) 
Performed: Sun-Sat 
Reported: 2-3 Day(s) 
CPT Codes:
84244 - Renin
Interpretive Data:
Adult, Normal Sodium Diet Reference Range:
Supine: 0.2-1.6 ng/ml/hr
Upright: 0.5-4.0 ng/ml/hr

Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen. Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.