91098 Factor V Leiden

Specimen:

Collect:

One 4 mL Lavender (EDTA)

Also Acceptable
One 4 mL Green Top (Li Heparin)
One 4 mL Blue Top (Na Citrate)

Submit:

4 mL (Min:3 mL) Whole blood. Submit Refrigerated.

Also Acceptable
One 4 mL Green Top (Li Hep). Submit Refrigerated.
One 4 mL Blue Top (Na Citrate). Submit Refrigerated.

Special Handling:

Special Form - Patient History for Molecular Genetics

Rejection Criteria:

Hemolyzed specimens

Stability:

Ambient: 3 Day(s); Refrigerated: 1 Week(s); Frozen: Unacceptable; Incubated: Unacceptable

Performed:

Sun-Sat

Reported:

3-5 Day(s)

CPT Codes:

83890 - Nuclear Molecular Diagnostics	83896 X2 - Nucleic Acid Probe
83898 - Molecular Diagnostics; Amplification of patient nucleic acid; Each Nucleic Acid	83912 - Molec Diag, Interp & Report

Interpretive Data:


The factor V Leiden mutation is the most common genetic risk factor for thrombosis and accounts for greater than 90% of cases with APC resistance. Inherited thrombosis due to APC resistance is considered an autosomal dominant disease. Heterozygote carriers of the factor V Leiden polymorphism have an increased risk of thrombosis of five- to tenfold and homozygotes have fifty- to one hundredfold increased risk.